ClinicalTrials.Veeva

Menu

Single-step Versus Sequential Media in Preimplantation Embryo Development and Pregnancy Rates

E

Eugonia

Status

Completed

Conditions

Infertility

Treatments

Other: Origio
Other: Global

Study type

Interventional

Funder types

Other

Identifiers

NCT02048527
Global versus Origio

Details and patient eligibility

About

Sequential culture media were introduced in order to meet the changing requirements of the developing embryo in vitro. However, there has been renewed interest in the use of single-step media, which allow the embryo itself to choose the necessary nutrients while maintaining a more stable culture environment. Previous studies suggest that sequential media do not appear superior to single-step media.

Full description

Sequential culture media were introduced in order to meet the changing requirements of the developing embryo in vitro. However, there has been renewed interest in the use of single-step media, which allow the embryo itself to choose the necessary nutrients while maintaining a more stable culture environment. Previous studies suggest that sequential media do not appear superior to single-step media.

The current study will include 2 RCTs:

RCT 1: Random allocation of sibling oocytes to compare embryo development and blastocyst formation rates in the two culture media compared.

RCT2: Random allocation of patients in either Global or Origio media, to evaluate pregnancy rates.

Enrollment

131 patients

Sex

Female

Ages

18 to 40 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • <40 years of age
  • female infertility patients
  • at least 10 retrieved oocytes

Exclusion criteria

  • 41 years or older
  • frozen-thawed oocytes/embryos
  • oocyte donation cycles

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Double Blind

131 participants in 2 patient groups

Global
Active Comparator group
Description:
In vitro embryo culture in single-step medium (Global)
Treatment:
Other: Global
Origio
Active Comparator group
Description:
In vitro embryo culture in sequential media (Origio)
Treatment:
Other: Origio

Trial contacts and locations

1

Loading...

Data sourced from clinicaltrials.gov

Clinical trials

Find clinical trialsTrials by location
© Copyright 2026 Veeva Systems