Single Versus Multiple Visits Endodontic Treatment

Cairo University (CU)

Status and phase: Completed; Phase 1

Conditions: Periapical Periodontitis

Treatments: Drug: mixture of metronidazole, ciprofloxacin, and minocycline

Study type: Interventional

Funder types: Other

Identifiers

NCT02947763

CEBD-CU-2016-10-231

Details and patient eligibility

About

Healing rate after single visit or multiple visit endodontic treatment using triple paste intracanal medicament will be assessed both clinically and radio-graphically for follow-up period up to one year

Full description

Patients with necrotic teeth with apical periodontitis will be selected according to the eligibility criteria and patients are then randomized to either single visit or multiple visit using triple paste intracanal medicament. Postoperative pain will then assessed using numerical rating scale after 1, 2, 3 and 7 days post-instrumentation. Radiographic healing will be assessed every 3 months up to one year.

Enrollment: 44 patients

Sex: All

Ages: 16 to 55 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Adult patients; age between 16-55 years old.

2. Males or Females.

3. Maxillary or mandibular single-root tooth or a multi-rooted tooth with:

   • Non-vital response of pulp tissue.
   • Radiographic evidence of periapical lesions (minimum size 2.0 mm × 2.0 mm) related to one root in case of multi-rooted teeth.
   • Asymptomatic patients.

4. Positive patients' acceptance for participation in the study.

Exclusion criteria

1. Primary teeth, and permanent teeth with immature apex.
2. Teeth previously accessed or endodontically treated.
3. Patients with diabetes and immune-compromising disease.
4. Patients allergic to metronidazole, ciprofloxacin, or minocycline.
5. Vital cases or necrotic without periapical lesion.
6. Pregnant women.
7. Teeth with unfavorable conditions for rubber-dam application.
8. Tooth associated with vertical root fracture, coronal perforation, calcification and external or internal root resorption.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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44 participants in 2 patient groups

multiple visit

Active Comparator group

Description:

multiple visit root canal treatment with triple antibiotic paste intracanal medication (a mixture of metronidazole, ciprofloxacin, and minocycline)

Treatment:

Drug: mixture of metronidazole, ciprofloxacin, and minocycline

single visit

No Intervention group

Description:

single visit root canal treatment without any intra-canal medication