Sinusitis in Children and the Nasopharyngeal Microbiome

University of Wisconsin (UW)

Status: Completed

Conditions: Sinusitis

Study type: Observational

Funder types: Other; NIH

Identifiers

NCT01492868

2015-0562

GRANT 10785179 (Other Identifier)

1R01AI097172-01 (U.S. NIH Grant/Contract)

2011-0535 (Other Identifier)

Details and patient eligibility

About

The purpose of this study is to investigate the relationship between viral infections of the upper respiratory tract, perturbations of the nasopharyngeal microbiome in children, and the risk of acute bacterial sinusitis over a one year period. The investigators will determine the incidence of acute bacterial sinusitis post viral upper respiratory infection and identify the viral antecedent infections and other risk factors which predispose to infection and ultimately design strategies to reduce the burden of disease and antimicrobial resistance.

Enrollment: 323 patients

Sex: All

Ages: 4 to 7 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Children 4 to 7 years of age
• Healthy
• English-speaking parent/guardian -

Exclusion criteria

• Any underlying condition which would predispose them to the development of sinusitis including congenital or acquired immunodeficiencies
• Craniofacial abnormalities
• Cystic fibrosis
• Allergic rhinitis or a previous episode of chronic sinusitis.

Trial design