Sirtuin Mediated Effects of 36 Hour Fast and 1 Hour Exercise

University of Aarhus

Status: Unknown

Conditions: Healthy

Treatments: Other: fast and exercise; Other: exercise

Study type: Interventional

Funder types: Other

Identifiers

NCT00978640

07.09.2009

Details and patient eligibility

About

Hypothesis: during fasting and exercise will there be an activation of sirtuins (Sirt1).

Primarily the investigators will investigate Sirt1 activity in muscle- and fat-biopsies after fasting for 36 hours and after 1 hour of ergometer-cycling at 50 Vo2max.

In addition to this the investigators will investigate the effect of fasting and exercise on the velocity of carbamide synthesis, aminoacid rate of turnover and glucose rate of turnover.

Enrollment: 8 estimated patients

Sex: Male

Ages: 18 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• healthy men
• Body mass index (BMI) 20-26
• age 18-45 years

Exclusion criteria

• any kind of disease
• any use of medicine

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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8 participants in 2 patient groups

fasting and exercise

Experimental group

Description:

36 h fast and 1 h ergometer cycling 50% VO2max

Treatment:

Other: fast and exercise

exercise

Experimental group

Description:

1 h ergometer cycling 50% VO2max

Treatment:

Other: exercise