Sit-to-stand Test in Cystic Fibrosis Children and Adolescents

Groupe Hospitalier du Havre

Status: Completed

Conditions: Cystic Fibrosis

Treatments: Behavioral: 6-Minute Walk Test; Behavioral: Sit-to-stand test

Study type: Interventional

Funder types: Other

Identifiers

NCT03069625

2016-A01377-44

Details and patient eligibility

About

Cystic fibrosis (CF) is a chronic hereditary respiratory disease. Exercise testing is part of CF patients regular assessment.

Cardio-Pulmonary Exercise Testing (CPET) is currently considered as the gold standard to assess physical capacities. However, simple field tests are emerging. These tests are easier to perform especially in a population of CF children and adolescents.

The 1minute Sit-To-Stand test have recently been evaluated in CF adults. This test correlates with maximal oxygen consumption during CPET.

The investigators hypothesized that this test also correlates with 6-Minute Walking distance (during a 6-min Walk Test), quadriceps strength, respiratory muscles strength and health-related quality of life.

Enrollment: 36 patients

Sex: All

Ages: 6 to 18 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Cystic Fibrosis
• Exacerbation-free last month before inclusion

Exclusion criteria

• Cardiovascular, neurological or musculoskeletal contra-indications to exercise testing
• Other respiratory disease (kyphoscoliosis, asthma ...)
• Exacerbation
• Unability to carry out field tests

Trial design

Primary purpose: Screening

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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36 participants in 2 patient groups

Sit-to-stand test

Experimental group

Description:

Children and adolescents will perform 2 STS tests. First one is used to eliminate learning effect. Number of repetitions will be noted at the end of the second test.

Treatment:

Behavioral: Sit-to-stand test

6-Minute Walk Test

Active Comparator group

Description:

Children and adolescents will perform 2 6MWT tests. First one is used to eliminate learning effect. Number of repetitions will be noted at the end of the second test.

Treatment:

Behavioral: 6-Minute Walk Test