Sjögren's Syndrome Is Associated With Meibomian Gland Dysfunction

Lanzhou University

Status: Unknown

Conditions: Meibomian Gland Dysfunction; Sjögren's Syndrome

Treatments: Drug: liposic; Drug: Tears Naturale Forte

Study type: Interventional

Funder types: Other

Identifiers

NCT03434106

2018A-005

Details and patient eligibility

About

The investigators hypothesize that the dry eye caused by SS may include the evaporative type, resulting from the MGD. Furthermore, the investigators hypothesize that both pSS and sSS are associated with MGD.To test our hypothesis, we conducted a prospective clinical study in patients with SS (both pSS and sSS) and MGD, and the normal population All subjects were matched for both age and gender and assessed for tear function and ocular surface signs and symptoms.

Enrollment: 60 estimated patients

Sex: Female

Ages: 45 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• All the subjects are female and age between 50-60 years
• Patients with primary SS fulfilled the criteria established by the European Study Group
• Patients with SLE and RA met the criteria set by the American College of Rheumatology

Exclusion criteria

• The control history of autoimmune disease

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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60 participants in 4 patient groups

primary Sjögren's syndrome

Experimental group

Description:

The female patients with primary Sjögren's syndrome receive the Tears Naturale Forte and Liposic.

Treatment:

Drug: Tears Naturale Forte

Drug: liposic

secondary Sjögren's syndrome

Experimental group

Description:

The female patients with secondary Sjögren's syndrome receive Tears Naturale Forte and Liposic.

Treatment:

Drug: Tears Naturale Forte

Drug: liposic

meibomian gland dysfunction

Experimental group

Description:

The female patients with meibomian gland dysfunction receive the Tears Naturale Forte and Liposic.

Treatment:

Drug: Tears Naturale Forte

Drug: liposic

control

Experimental group

Description:

the female had no history of autoimmune disease receive the Tears Naturale Forte and Liposic.

Treatment:

Drug: Tears Naturale Forte

Drug: liposic