Skeletal Muscle and Platelet Mitochondrial Dysfunction During Sepsis

Institute of Hospitalization and Scientific Care (IRCCS)

Status: Completed

Conditions: Severe Sepsis; Septic Shock

Study type: Observational

Funder types: Other

Identifiers

NCT00541827

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Details and patient eligibility

About

The primary aim of the study is to demonstrate that mitochondrial dysfunction occurs in both skeletal muscle and circulating platelets of severely septic and septic shock ICU-admitted patients. Secondary aims are to clarify the pathogenesis and the clinical relevance of mitochondrial damage during sepsis.

Full description

The primary aim of the study is to demonstrate that mitochondrial dysfunction occurs in both skeletal muscle and circulating platelets of severely septic and septic shock ICU-admitted patients, as compared to otherwise healthy surgical ones. In order to better clarify the pathogenesis of mitochondrial dysfunction during sepsis, cardiogenic shock patients (suffering from systemic hypoperfusion) will act as additional controls. Markers of oxidative stress will be measured in tissue samples from septic patients. The clinical relevance of mitochondrial dysfunction during sepsis will be assessed in terms of both skeletal muscle and platelet function.

Enrollment: 50 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Consecutive ICU-admitted severely septic or septic shock patients.

Exclusion criteria

• Severe thrombocytopenia.
• Severe coagulopathy.
• Pre-existing mitochondrial disease