Skeletal Muscle as a Mediator of Exercise Induced Effects on Metabolism & Cognitive Function: Role for Myokines & miRNAs (Brain-Muscle)

Slovak Academy of Sciences

Status: Completed

Conditions: Healthy Volunteers; Alzheimer Disease; Mild Cognitive Impairment; Parkinson Disease

Treatments: Behavioral: 3 months exercise intervention program

Study type: Interventional

Funder types: Other

Identifiers

NCT02253732

UEE-SAS

Details and patient eligibility

About

The purpose of this study is to determine specific changes in muscle secretory profile (myokines, miRNA) in association with neurodegenerative disease progression and metabolic dysfunction. Next the investigators would like to determine the shift in the muscle secretory activity induced by regular exercise intervention, which the investigators think could be translated into the beneficial changes in clinical phenotypes, determined by neuroimaging, cognitive function tests and metabolic phenotyping.

Full description

Standard Operating Procedures for patient recruitment, data collection, data management, data analysis routinely used in University Hospital Bratislava and in Institute of Experimental Endocrinology Slovak Academy of Sciences will be employed.

Statistical analysis will be employed to address the primary and secondary objectives, as specified in the study protocol.

Enrollment: 30 patients

Sex: All

Ages: 60 to 85 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Signed informed consent.
2. Diagnosed with Parkinson disease
3. Diagnosed with mild cognitive impairment (MCI) or Alzheimer disease (AD)

Exclusion criteria

1. Serious systemic cardiovascular, hepatic, renal disease, cancer.
2. Lack of compliance.

Trial design

Primary purpose: Prevention

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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30 participants in 1 patient group

'3 months exercise intervention program'

Experimental group

Description:

all participants will be subjected to 3 months supervised exercise intervention programme

Treatment:

Behavioral: 3 months exercise intervention program