Skeletal Muscle Dysfunction in Heart Failure

Ullevaal University Hospital

Status: Unknown

Conditions: Heart Failure, Congestive

Treatments: Behavioral: One-knee extension ergometer

Study type: Interventional

Funder types: Other

Identifiers

NCT00156234

TRUST-001

Helse Øst

Helse og rehabilitering

Details and patient eligibility

About

Patients suffering from congestive heart failure report reduced exercise capacity. This skeletal muscle dysfunction is also detectable when using small muscle groups which should not put any demand on the heart.

We hypothesize that congestive heart failure has systemic effects that causes the skeletal muscle dysfunction.

Sex: All

Ages: 40 to 78 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Coronary Heart Failure
• Ejection fraction <35%
• NYHA 2-3
• Spirometry FEV1 > 80%

Exclusion criteria

• Cardiomyopathy
• Transplantation candidate
• Active malignancy
• Restraining skeletal-muscular disease
• Claudication in legs
• Hospitalized last 30 days due to acute ischemic episode
• Intravenous inotrope or vasodilatating drugs last 14 days prior to inclusion
• AMI last 8 weeks prior to inclusion
• Organized training last 4 months
• Smoking on daily basis last 4 months
• Creatinin < 150microliters/liter

Trial design

Primary purpose: Educational/Counseling/Training

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind