Skeletal Muscle Energetics and Fatiguability in Older Individuals

Johns Hopkins University

Status

Enrolling

Conditions

HIV

HIV Infections

Study type

Observational

Funder types

Other

NIH

Identifiers

NCT04142047

R01AG063661 (U.S. NIH Grant/Contract)

IRB00197581

Details and patient eligibility

About

The investigators are studying whether metabolic abnormalities in calf (leg) muscle in older people with and others without HIV are associated with decreased abilities to exercise.

Full description

This research is being done to better understand why some older people living with HIV experience more fatigue and difficulty exercising than older people without HIV. This is important because fatigue and problems exercising are predictors of disability and hospitalization in older individuals. We will use non-invasive magnetic resonance imaging (MRI) and spectroscopy (MRS) of the leg muscle to measure muscle metabolites and fat content, as well as blood samples measures levels of inflammation.

Enrollment

200 estimated patients

Sex

All

Ages

60 to 90 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Participants who are >= 60 years of age
HIV serostatus positive participants on stable antiretroviral therapy (ART) (no regimen change in last month) with undetectable HIV viral load (<100 copies).
HIV serostatus negative participants

Exclusion criteria

Unable to understand the risks, benefits, and alternatives of participation and give meaningful consent
Contraindications to MRI
Significant cardiovascular, pulmonary or musculoskeletal or orthopedic disease that significantly limits exercise capacity
Significant lower extremity peripheral vascular disease.
Weight greater than 350 lbs
Cognitive or speech impairments that would limit completion of questionnaires or fatigue reporting.