Skeletal Muscle Energy Metabolism in Women With Weight Loss and Ovarian and/or Endometrial Cancer With Weight Loss (METERMUS-IMC)

Regional University Hospital Center (CHRU)

Status: Completed

Conditions: Endometrial Carcinoma; Weight Loss; Ovarian Carcinoma

Treatments: Other: Samples

Study type: Interventional

Funder types: Other

Identifiers

NCT03027479

PHAO16-LO/METERMUS-IMC

2016-R27 (Other Identifier)

2016-A01323-48 (Registry Identifier)

Details and patient eligibility

About

the aim is to study skeletal muscle metabolism alterations métaboliques associated with weight loss in women with ovarian and/or endometrial cancer according to BMI.

Enrollment: 70 patients

Sex: Female

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Case group selection criteria:

Inclusion Criteria:

• Women aged 18 years old and more
• Ovarian and/or endometrial cancer
• weight loss related to cancer (weight loss > 5% weight in one month or 10% in 6 months)
• Indication to therapeutic surgery
• Women affiliated to social security scheme
• Women who can understand French and able to sign Informed consent

Exclusion Criteria:

• Unbalanced Diabetes
• Chronic neuromuscular disorder
• Any severe uncontrolled medical condition

Control group selection criteria:

Inclusion Criteria:

• Women aged 18 years and more
• Surgery Indication for a benign endometrial and/ or ovarian disease
• Patient affiliated to social security scheme
• Women who can understand French and able to sign Informed consent

Exclusion Criteria:

• Unbalanced Diabetes
• Chronic neuromuscular disorder
• Any severe uncontrolled medical condition

Trial design

Primary purpose: Health Services Research

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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70 participants in 2 patient groups

Case group

Experimental group

Description:

women with ovarian and/or endometrial cancer and weight loss will have muscle, adipose tissue, ovarian tumor and blood samples

Treatment:

Other: Samples

Control group

Other group

Description:

women scheduled for an intervention for benign ovarian/ endometrial disease and no weight loss will have muscle, adipose tissue and blood samples

Treatment:

Other: Samples