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Skeletal Muscle Perfusion With LVAD

Oregon Health & Science University (OHSU) logo

Oregon Health & Science University (OHSU)

Status

Unknown

Conditions

Heart Failure

Treatments

Other: Contrast ultrasound skeletal muscle perfusion imaging

Study type

Observational

Funder types

Other

Identifiers

NCT02105831
CEU in LVAD

Details and patient eligibility

About

Advanced heart failure (when the heart pump fails) is associated with symptoms such as shortness of breath and extreme fatigue. Some of these symptoms are simply due to failure of the pump, however abnormal regulation of blood flow to the muscles of the body is also a potential mechanism. Left ventricular assist devices are mechanical pumps used to compensate for patients with failing hearts either as a bridge to heart transplant or as long term therapy. Whether or not these pumps improve muscle flow and whether this is a determinant in the improvement of symptoms is unknown. Understanding how skeletal muscle and heart perfusion is altered in heart failure patients before and after implantation of an LVAD could provide further insight into the beneficial effects of this therapy.

Specific Aims:

  1. To evaluate skeletal muscle and heart perfusion studies before and after LVAD implantation
  2. To compare functional status with degree of skeletal muscle perfusion.

Full description

Methods:

Thirty patients deemed to be candidates for LVAD from either outpatient heart failure clinic or inpatient cardiology service will be studies. Skeletal muscle perfusion imaging using standard of care ultrasound technology will be performed prior to LVAD implant and then 3 months post implant. Functional status by six minute walk test and specialized stress test will be assessed at 3 months post implant.

Enrollment

30 estimated patients

Sex

All

Ages

18 to 70 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • patients deemed to be candidates for a LVAD

Exclusion criteria

  • severe peripheral artery disease
  • skeletal muscle disorder
  • severe congenital heart disease
  • pregnancy
  • patients <18 yo

Trial design

30 participants in 1 patient group

CEU skeletal muscle perfusion imaging
Description:
Heart failure with LVAD Contrast ultrasound skeletal muscle perfusion imaging
Treatment:
Other: Contrast ultrasound skeletal muscle perfusion imaging

Trial contacts and locations

1

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Central trial contact

Jonathan R Lindner, MD

Data sourced from clinicaltrials.gov

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