Skin Barrier Biophysical Properties and Clinical Appearance After Moisturizer in Dry Skin

University of Arizona

Status: Completed

Conditions: Xerosis Cutis; Xerosis; Dry Skin; Eczema

Treatments: Other: virgin almond oil; Other: white petrolatum ointment; Other: virgin jojoba oil; Other: virgin coconut oil

Study type: Interventional

Funder types: Other

Identifiers

NCT03093597

1701110479

Details and patient eligibility

About

The purpose of the study is to compare the changes in the appearance of dry skin after the use various moisturizers: white petrolatum ointment, coconut oil, jojoba oil, and almond oil in patients with dry skin.

Full description

The goal of this study is to compare how the appearance of dry skin changes before and after the use of following moisturizers: white petrolatum, coconut oil, jojoba oil and almond oil). Up to 40 subjects from Banner-University Medical Center/University of Arizona dermatology clinics and University of California, Davis dermatology clinics (up to 20 subjects per site) who have dry skin will be enrolled in this study and randomized to receive the four moisturizers on four locations on their forearms.There will be a total of 3 study sessions: baseline, and approximately 1 and 2 weeks for follow up assessment. At each visit, dry skin severity will be evaluated by a trained observer using a validated Dry Skin Score, skin barrier biophysical properties (transepidermal water loss and hydration) will be measured, and digital photos of the test sites will be taken for image analysis.

Enrollment: 37 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Male and female, at least 18 years of age
2. Subject must receive a diagnosis of dry skin by a dermatologist.
3. Subject must be able to comprehend and read the English language.

Exclusion criteria

1. Subjects who do not fit the inclusion criteria.
2. Subjects unable to or unwilling to comply with the study procedures
3. Prior known allergy to white petrolatum, coconut oil, almond oil, or jojoba oil.
4. People who have used products containing white petrolatum, jojoba oil, coconut oil, or almond oil within the past week.
5. People with a known diagnosis of ichthyosis.
6. A subject who, in the opinion of the investigator, will be un-cooperative or unable to comply with study procedures.
7. Subject unable to speak or read the English language, since all consents and instructions will be provided in English.
8. Those that are prisoners or cognitively impaired

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)

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37 participants in 4 patient groups

virgin coconut oil

Active Comparator group

Description:

All subjects will apply virgin coconut oil to a previously randomize section of the skin on the left or right forearm.

Treatment:

Other: virgin coconut oil

virgin jojoba oil

Active Comparator group

Description:

All subjects will apply virgin jojoba oil to a previously randomize section of the skin on the left or right forearm

Treatment:

Other: virgin jojoba oil

virgin almond oil

Active Comparator group

Description:

All subjects will apply virgin almond oil to a previously randomize section of the skin on the left or right forearm

Treatment:

Other: virgin almond oil

white petrolatum ointment

Active Comparator group

Description:

All subjects will apply white petrolatum ointment to a previously randomize section of the skin on the left or right forearm.

Treatment:

Other: white petrolatum ointment