Skin Conductance for Predicting Spinal Anesthesia-Induced Hypotension in Geriatric Urologic Oncology Patients

Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital

Status: Enrolling

Conditions: Hypotension; Spinal Anesthesia; Aged; Urologic Neoplasms

Treatments: Other: Skin Conductance Monitoring

Study type: Observational

Funder types: Other

Identifiers

NCT07481851

2025-12/205

Details and patient eligibility

About

Spinal anesthesia-induced hypotension is a common and clinically significant complication in elderly patients undergoing oncologic surgery. Early identification of patients at risk for hemodynamic instability remains a major challenge in perioperative management. Skin conductance reflects sympathetic nervous system activity and may provide a noninvasive indicator of autonomic responses. This prospective observational study aims to evaluate whether skin conductance measurements can predict the development of hypotension following spinal anesthesia in geriatric oncology patients undergoing urologic surgery. The findings may contribute to improved perioperative monitoring and early risk stratification in this vulnerable patient population.

Full description

Spinal anesthesia is widely used in urologic oncology surgery due to its favorable analgesic profile and reduced systemic anesthetic exposure. However, spinal anesthesia frequently leads to significant hemodynamic changes, particularly hypotension, which is more pronounced in elderly patients because of age-related alterations in autonomic regulation, reduced cardiovascular reserve, and increased comorbidity burden. Spinal anesthesia-induced hypotension may result in inadequate tissue perfusion and increased perioperative morbidity, making early identification of patients at risk an important aspect of perioperative management.

Skin conductance is a noninvasive physiological parameter reflecting sympathetic nervous system activity and sudomotor responses. Changes in skin conductance have been associated with variations in autonomic nervous system activity and may provide an indirect indicator of hemodynamic responses. Continuous monitoring of skin conductance may therefore offer a potential method for identifying patients who are more likely to develop hypotension after spinal anesthesia.

The aim of this prospective observational study is to investigate the relationship between skin conductance measurements and the development of hypotension following spinal anesthesia in geriatric oncology patients undergoing urologic surgery. Hemodynamic parameters including blood pressure and heart rate will be monitored perioperatively, and their association with skin conductance measurements will be evaluated. The results of this study may contribute to improving perioperative monitoring strategies and risk prediction in elderly oncology patients undergoing spinal anesthesia.

Enrollment: 102 estimated patients

Sex: All

Ages: 65+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients aged 65 years and older
• Patients scheduled for elective urologic oncology surgery under spinal anesthesia
• American Society of Anesthesiologists (ASA) physical status I-III
• Patients who provide written informed consent to participate in the study

Exclusion criteria

• Refusal to participate or inability to provide informed consent
• Contraindication to spinal anesthesia (e.g., infection at puncture site, coagulopathy)
• Severe cardiac conduction abnormalities or presence of a cardiac pacemaker
• Severe autonomic dysfunction or known neuropathy affecting autonomic responses
• Use of medications that significantly affect autonomic nervous system activity
• Baseline hypotension or hemodynamic instability before spinal anesthesia
• Inability to obtain reliable skin conductance measurements (e.g., severe skin lesions at electrode placement site)

Trial design

102 participants in 1 patient group

Geriatric Urologic Oncology Patients Undergoing Spinal Anesthesia

Description:

Geriatric patients undergoing urologic oncology surgery under spinal anesthesia will be prospectively observed. Skin conductance will be continuously monitored perioperatively as a noninvasive indicator of sympathetic nervous system activity. Hemodynamic parameters, including blood pressure and heart rate, will be recorded before and after spinal anesthesia. The occurrence of spinal anesthesia-induced hypotension will be assessed and its association with skin conductance measurements will be evaluated.

Treatment:

Other: Skin Conductance Monitoring