Skin Sparing Mastectomy and Immediate Breast Reconstruction With Latissimus Dorsi Flap After Neoadjuvant Chemotherapy and Radiotherapy (M-RIC)

Clinique Clementville

Status and phase: Unknown; Phase 2

Conditions: Breast Carcinoma

Treatments: Procedure: Mastectomy, preservation of the skin envelope,followed by immediate reconstruction with autologous latissimus dorsi flap.

Study type: Interventional

Funder types: Other

Identifiers

NCT01199354

CLEM-01

Details and patient eligibility

About

The aim of the study is to evaluate the feasibility and morbidity of skin sparing mastectomy and immediate breast reconstruction with latissimus dorsi flap after neoadjuvant chemotherapy and radiotherapy in invasive breast carcinoma.

Enrollment: 80 estimated patients

Sex: Female

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Women < 75 year old
• Invasive breast carcinoma, indication for mastectomy
• Women Health Organization (WHO) score of 0 and 1, primary chemotherapy, external radiotherapy performed less than 8 week earlier...

Exclusion criteria

• Women older than 75
• Metastatic breast carcinoma
• Antecedents of previously treated homolateral breast carcinoma
• Documented cancer progression
• Smoker at the moment of the indication surgery
• Known diabetes, neoadjuvant hormonal treatment...