Sleep and Central Auditory Processing Disorder in Autism Spectrum Disorder (ASD)

Loma Linda University (LLU)

Status: Enrolling

Conditions: Autism Spectrum Disorder; Sleep Disturbance; Central Auditory Processing Disorder

Study type: Observational

Funder types: Other

Identifiers

NCT06059352

5210160

Details and patient eligibility

About

The proposed study aims to understand poor sleep as a possible cause to CAPD in children and adolescents with ASD (ASD+) compared to ASD youth without CAPD (ASD-), using both caregiver-report and objective clinician administered measures. Additionally, the study will aim to understand the complex relationship between CAPD, sleep, and other associated phenotypic features of ASD such as executive and psychiatric functioning.

Full description

Participation will involve one assessment session approximating 4 hours including administration of neurocognitive and socioemotional measures by trained research staff. The research team then will determine which participants meet CAPD diagnostic criteria for both the SCAN-3 and RGDT tests and assign them to the ASD+ group. Participants not meeting these criteria will be assigned to the ASD- group. Following the assessment visit, all participants will then be asked to wear actigraphy monitors (comparable to overnight polysomnography) regularly for 14 days during nighttime sleep to objectively measure sleep quality.

Enrollment: 100 estimated patients

Sex: All

Ages: 6 to 17 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Have diagnosis of Autism Spectrum Disorder confirmed by the Autism Diagnostic Observation Schedule and the Social Communication Questionnaire, Lifetime Version which will be filled by the parent
• IQ of 50 or higher on the Abbreviated Battery IQ Score

Exclusion criteria

• No confirmed diagnosis of Autism Spectrum Disorder
• History of sleep apnea
• History of restless leg syndrome
• History of any neurological disorders (e.g., seizures, tumors, etc.)
• Significant substance use in the past six months
• Inpatient hospitalization in the past three months-period

Trial design

100 participants in 2 patient groups

ASD+ CAPD

Description:

This group includes children and adolescence with ASD who also have CAPD. No intervention will be applied to this group.

ASD- CAPD

Description:

This group includes children and adolescence with ASD who are not affected by CAPD. No intervention will be applied to this group.