Sleep and Circadian Contributions to Nighttime Blood Pressure (SCN-BP)

The University of Alabama at Birmingham

Status: Invitation-only

Conditions: Hypertension; Circadian Rhythm; Blood Pressure; Sleep

Treatments: Other: Constant Routine Protocol

Study type: Interventional

Funder types: Other

Identifiers

NCT05656768

IRB-300010042

Details and patient eligibility

About

Broadly, this study (SCN-BP) seeks to examine sleep and circadian factors that contribute to blood pressure levels at night.

Full description

SCN-BP is imbedded in a parent grant titled "Improving the Detection of Hypertension (IDH-MEGA)" and examines a variety of sleep (e.g., sleep duration, timing, and the presence of sleep disorder) and circadian factors in Aims 1 and 2. In Aim 3, the investigators will conduct a 30-hour constant routine protocol to directly examine endogenous circadian and blood pressure rhythms. Aims 1 and 2 are purely observation. The study design design described below pertains the intervention piece of this study (Aim 3).

Enrollment: 1,427 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Participant in the parent grant (IDH-MEGA)

Exclusion criteria

-

Trial design

Primary purpose: Other

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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1,427 participants in 1 patient group

Constant Routine Protocol

Experimental group

Description:

Participants complete a 30-hour constant routine protocol to directly examine markers of endogenous circadian rhythms. In a constant routine protocol, participants remain in a dimly lit room (\<10 lux), in a semi-recumbent posture, remain awake, and consume iso-caloric snacks. Saliva samples are collected and core body temperature and blood pressure are measured.

Treatment:

Other: Constant Routine Protocol