Sleep and Memory in Children (EnSOM)

Civil Hospices of Lyon

Status

Completed

Conditions

Healthy Subject

High Intellectual Potential

Sleep Apnea

Temporo-central Epilepsy

Narcolepsy

Treatments

Other: memory evaluation at V1 and V2 (with treatment)

Other: memory evaluation at V1 (without treatment)

Other: memory evaluation at V1 and V2 (without treatment)

Study type

Interventional

Funder types

Other

Identifiers

NCT02785328

69HCL15_0226

Details and patient eligibility

About

Sleep exerts a dual effect on learning: on the one hand, good sleep quality allows good daytime aptitudes leading to knowledge acquisition. On the other hand, sleep after learning is necessary for knowledge consolidation. A key role of sleep has clearly been demonstrated in memory consolidation in adults. Sleep leads to strengthen memory by promoting brain plasticity. Surprisingly, sleep influence on learning stabilization has scarcely been studied during childhood and in children affected by sleep disorders. Yet, sleep disorders concern almost 30% of children and are frequently related to a worsening in academic performances. Classical neuropsychological evaluations of these children, based on daytime learning, often fail to determine cognitive profiles explaining their academic difficulties. The investigators hypothesize that a lack of sleep-dependent consolidation could take an active part in these children's cognitive and academic difficulties. This proposal aims at characterizing interactions between sleep, learning and memory processes that have not been studied in children of elementary school age (6-12 years). The investigators will evaluate sleep-dependent memory consolidation processes in children with sleep disorders before and after treatment and healthy controls. Neuropsychological testing and academic performances will be also evaluated.. The comparison of performances obtained before and after medical treatment, will allow to understand whether normalisation of sleep quality permits the restoration of sleep-dependent memory consolidation.

Enrollment

71 patients

Sex

All

Ages

6 to 12 years old

Volunteers

Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

aged between 6 and 12 y
referred to the HFME for a suspicion of sleep apnea
narcolepsy
centro-temporal epilepsy
high intellectual potential
children without sleep disorders will be included in the healthy control group.

Trial design

Primary purpose

Basic Science

Allocation

Non-Randomized

Interventional model

Parallel Assignment

Masking

None (Open label)

71 participants in 5 patient groups

obstructive sleep apnoea

Experimental group

Description:

The objective of this task is to evaluate the sleep-dependent consolidation abilities before and after treatment in children suffering from obstructive sleep apnoea syndrome.

Treatment:

Other: memory evaluation at V1 and V2 (with treatment)

narcolepsy

Experimental group

Description:

The objective of this task is to evaluate the sleep-dependent consolidation abilities before and after treatment in children suffering from narcolepsy.

Treatment:

Other: memory evaluation at V1 and V2 (with treatment)

BECTS (Benign epilepsy with centro-temporal spikes)

Experimental group

Description:

The objective of this task is to evaluate the sleep-dependent consolidation abilities before and after treatment in children suffering from BECTS.

Treatment:

Other: memory evaluation at V1 and V2 (with treatment)

high intellectual potential

Experimental group

Description:

The objective of this task is to evaluate the sleep-dependent consolidation abilities in children with high intellectual potential.