Sleep and Rehearsal-Driven Memory in Epilepsy (CORESOM-EPI)

Civil Hospices of Lyon

Status: Enrolling

Conditions: Memory Consolidation; Epilepsy

Treatments: Other: Eye tracking; Other: Questionnaires on task-related fatigue; Other: Questionnaire on task difficulty; Other: Karolinska scale; Other: Cognitive memory task on a computer

Study type: Observational

Funder types: Other

Identifiers

NCT06967935

2025-A00510-49 (Other Identifier)

69HCL25_0188

Details and patient eligibility

About

Memory consolidation transforms unstable memory traces into lasting representations, a process enhanced by both sleep and rehearsal during learning. Rehearsal is thought to accelerate consolidation by inducing memory reactivations that resemble those occurring during sleep. However, the respective mechanisms of sleep- and rehearsal-induced consolidation-and their potential interactions-remain poorly understood, especially in patients with temporal lobe epilepsy, where rehearsal might help compensate for memory deficits linked to hippocampal dysfunction, and where sleep may exacerbate epileptic activity. The CORESOM-EPI study aims to compare the effects of rehearsal and sleep on memory consolidation in patients undergoing video-EEG monitoring. Participants will learn "object-place" associations under two conditions (single versus repeated encoding), with memory tested immediately and again after a 12-hour delay. This delay will either include a full day awake or a night of sleep, allowing direct comparison of sleep- and rehearsal-related consolidation effects. Each participant will perform the task twice, with "wake" and "sleep" condition, in a balanced order. As a preliminary phase of the CRIMES study (ANR-DFG 2024), CORESOM-EPI will help assess how sleep and rehearsal influence memory consolidation in epilepsy. It will also serve to adapt the behavioral task for clinical use, paving the way for a future intracranial EEG investigations that will explore the neural networks involved and their modulation by epileptic activity.

Enrollment: 20 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patient with epilepsy (any type of epilepsy)
• Hospitalized for video-EEG recording lasting at least 4 days
• Aged 18-65 years

Exclusion criteria

• Major cognitive impairment other than memory deficit
• Refusal to participate
• Pregnant women, women in labor or nursing mothers
• Persons deprived of their liberty by judicial or administrative decision
• Persons under psychiatric care
• Persons admitted to a health or social institution for purposes other than research
• Adults under legal protection (guardianship, curatorship)

Trial design

20 participants in 2 patient groups

WAKE - SLEEP

Description:

This group will start with the condition 1 " wake " (encoding+immediate recall in the morning (8 :00am) and delayed recall in the evening (8 :00pm)) and will end with the condition 2 " sleep " : (encoding+immediate recall in the evening (8 :00pm) and delayed recall in the morning (8 :00am))

Treatment:

Other: Cognitive memory task on a computer

Other: Karolinska scale

Other: Questionnaire on task difficulty

Other: Questionnaires on task-related fatigue

Other: Eye tracking

SLEEP-WAKE

Description:

This group will start with the condition 2 " sleep "and will end with the condition 1 " wake "

Treatment:

Other: Cognitive memory task on a computer

Other: Karolinska scale

Other: Questionnaire on task difficulty

Other: Questionnaires on task-related fatigue

Other: Eye tracking