Sleep, Autonomic Nervous System and Cardiorespiratory Capacity in Autism Spectrum Disorders Children (APAUTRES)

Grenoble Alpes University Hospital Center (CHU)

Status: Completed

Conditions: Autonomic Nervous System Diseases; Sleep

Treatments: Other: physiological explorations

Study type: Interventional

Funder types: Other

Identifiers

NCT02830022

38RC14.123

Details and patient eligibility

About

Autism Spectrum Disorders (ASD) is a neurodevelopmental disorder which involves social and behavioural impairments. Autonomic dysfunctions and disturbed sleep were often associated to ASD. The investigators proposed to explore the impact of physical activity on these disorders. In this context, it is necessary to characterize the cardiorespiratory capacities of ASD children in order to promote physical activity for this population. To examine potential differences between ASD and control children, some explorations were proposed: a maximal treadmill test, motor evaluation, and orthostatic test (for the evaluation of autonomic nervous system).

An actimetry during one week (evaluation of physical activity and sleep) completed this study in order to specify sleep characteristic and established the possible link between physical activity sleep characteristics and physical fitness in ASD children.

Enrollment: 78 patients

Sex: All

Ages: 8 to 18 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• children physically active
• children with an intellectual quotient >70
• for autism children a diagnosis of autism in accordance to DSMV

Exclusion criteria

• history of cardio-vascular disease
• history of asthma or respiratory disease
• Behavior disorders.
• medical treatment by neuroleptic or melatonin or antiepileptic

Trial design

Primary purpose: Diagnostic

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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78 participants in 2 patient groups

Patients

Experimental group

Description:

Children from 8 to 18 years with autism without without intellectual disabilities (IQ \> 70), verbals and responding to classification CIM 10-DSM IV.

Treatment:

Other: physiological explorations

Healthy volunteers

Experimental group

Description:

Paired for age, gender, IQ and and the practice of a physical activity strictly within the school context.

Treatment:

Other: physiological explorations