Sleep, Circadian Rhythms and Cluster Headache

University of Surrey

Status: Completed

Conditions: Cluster Headache

Treatments: Other: Actigraphy; Other: Polysomnography

Study type: Observational

Funder types: Other

Identifiers

NCT01447641

CRC301

Details and patient eligibility

About

The purpose of this study is to assess both the sleep and circadian (24-hourly biological rhythms) physiology of people with cluster headache. For sufferers with the episodic form of the disorder this will involve observation at two separate time points, once when experiencing attacks (in-bout) and once when attack free (out-of-bout).

The study will include measurement of basic rest-activity patterns, sleep timing and timing of individual attacks, as well as a more detailed study recording sleep and circadian rhythms under clinical conditions over consecutive nights.

Studying the differences in these processes in single individuals when they are both experiencing and free from attacks might provide insight into the brain mechanisms involved in triggering the bouts of attacks and individual attacks themselves. An improved understanding of this area may help design improved treatment options in future.

Enrollment: 8 patients

Sex: All

Ages: 16 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Diagnosis of cluster headache or closely related primary headache disorder

Exclusion criteria

• Abnormality on screening investigations that increase risk of participation
• Alcohol consumption exceeding 21 units per week

Trial design

8 participants in 1 patient group

Cluster headache

Description:

Cluster headache sufferers (both chronic and episodic)

Treatment:

Other: Actigraphy

Other: Polysomnography