Sleep-dependent Learning in Aging

University of Massachusetts, Amherst logo

University of Massachusetts, Amherst

Status

Enrolling

Conditions

Sleep

Treatments

Behavioral: Sleep

Study type

Interventional

Funder types

Other

Identifiers

NCT03840083
2017-4290

Details and patient eligibility

About

The specific objective of this proposed research is to understand whether deficits in sleep-dependent memory changes reflect age-related changes in sleep, memory, or both. The central hypothesis is that changes in both memory and sleep contribute to age-related changes in sleep-dependent memory processing. To this end, the investigators will investigate changes in learning following intervals of sleep (overnight and nap) and wake in young and older adults.

Full description

Exp 1: Using neuroimaging, the investigators will consider whether differences in brain areas engaged during memory encoding contribute to age-related changes in sleep-dependent memory consolidation for a word-pair learning task. Exp 2: The investigators will examine the rate of memory decay between encoding and sleep using two probes of declarative memory (word-pair learning and visuo-spatial learning). Exp 3: The investigators will provide additional opportunity for encoding of the word-pair and visuo-spatial learning tasks. Exp 4: Using neuroimaging, the investigators will examine neural engagement during encoding and performance following intervals of sleep and wake. Exp 5: The investigators will examine the rate of decay of motor sequence learning. Exp 6: The investigators will examine whether enhanced training ('overtraining') improves sleep-dependent memory consolidation for older adults.

Enrollment

584 estimated patients

Sex

All

Ages

18 to 75 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Age 18-75 yrs Healthy sleeper No diagnosed sleep or neurodegenerative disorder

Exclusion criteria

Past diagnosis of any sleep disorder or evidence of a sleep disorder as assessed by self-reported sleep quality assessments, a standardized diagnostic interview, and an acclimation night of polysomnography. Using acclimation-night polysomnography, participants will be excluded with an Apnea-Hypopnea Index >15; a Period-Limb Movement in Sleep index of >15/hr; sleep-onset latency > 45 min (indicative of insomnia); or sleep efficiency < 80% (see Edinger et al., Sleep, 2004). In cases in which questions arise regarding a participants' inclusion or sleep records, a practicing neurologist board-certified in sleep medicine will review the documentation. Past diagnosis neurological illness or head injury Reported average sleep per night < 5 or > 9 hrs Current employment involving shift work or an inability to keep a regular sleep schedule during the week prior to testing Current use of psychotropic, recreational drugs, or sleep-altering medications (sleep medications, cold medicines within the past week, clonidine, sympathomimetic stimulants) Daily caffeine intake of > 4 cups (coffee, tea, colas) Weekly alcohol intake of > 10 cups Pregnancy or < 12 months post-partum History of bipolar disorder, mania, or current evidence of depression as measured by Beck Depression Inventory score > 25 Abnormal sleep (e.g., shift work, travel across >2 time zones within the past 3 months). Diagnosis of any Axis I disorder, neurological illness or head injury (according to Demographic and Health History form); Score indicative of cognitive dysfunction (subtest scores < 40) Beck Depression Scale score indicative of depression (> 19). Additionally, individuals will be excluded from magnetic resonance imaging studies (Exps 1, 4) for: Left handed or ambidextrous Claustrophobia Presence of metal (thoroughly screened via questionnaire and metal detector) Pregnancy

Trial design

Primary purpose

Basic Science

Allocation

Non-Randomized

Interventional model

Parallel Assignment

Masking

None (Open label)

584 participants in 2 patient groups

Sleep
Experimental group
Description:
Individuals will either nap (Exps 1, 4) or have overnight sleep (Exps 2, 3, 5, 6)
Treatment:
Behavioral: Sleep
Wake
No Intervention group
Description:
Individuals will stay awake for the same amount of time as they slept in the sleep condition

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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