Sleep Deprivation and Advancement of Sleep Period as Treatment for Bipolar Depression.

Norwegian University of Science and Technology

Status: Terminated

Conditions: Bipolar Disorder

Treatments: Behavioral: Sleep deprivation and sleep phase advancement; Other: usual treatment

Study type: Interventional

Funder types: Other

Identifiers

NCT00229151

S2005.1.depr

Details and patient eligibility

About

The purpose of this study is to determine if sleep deprivation and sleep phase advancement is effective treatment of bipolar patients in a depressive phase.

Full description

Background: The onset of therapeutic action for most anti-depressive treatments is usually two weeks. During this period patients suffer from great symptomatic distress. Treatment options that are effective in this period is therefore of interest for psychiatric wards.

Aim: To explore if sleep deprivation and three days sleep phase advancement is effective treatment for inpatients with bipolar disorder in a depressive phase.

Method: A randomized controlled trial with 24 patients diagnosed with bipolar disorder. Patients will be randomized to treatment as usual in an psychiatric ward, or sleep deprivation and three days sleep phase advancement. Patients in the treatment as usual group will be offered treatment with sleep deprivation and sleep phase advancement after five weeks if they still meet inclusion criteria.

Enrollment: 5 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Bipolar disorder, depressive phase

Exclusion criteria

• substance abuse, psychotic symptoms, suicidal intentions, active mania/hypomania.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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5 participants in 2 patient groups

Sleep deprivation

Experimental group

Description:

Sleep deprivation and sleep phase advancement

Treatment:

Behavioral: Sleep deprivation and sleep phase advancement

usual treatment

Active Comparator group

Treatment:

Other: usual treatment