Sleep Deprivation's Regulation of Immune System Function and Behavior (SS)

Uppsala University

Status: Unknown

Conditions: Sleep Deprivation; Sleep

Treatments: Behavioral: Neuroeconomics task; Behavioral: Portion Size Task; Procedure: Blood sample

Study type: Interventional

Funder types: Other

Identifiers

NCT01730742

192837465

Details and patient eligibility

About

The study proposes to investigate whether sleep deprivation will affect a variety of measures, including hormones, immune system functioning, and behaviors related to food intake and hunger. It is predicted that sleep deprivation will affect circulating neutrophil activity, and do so via affects on DNA methylation. It is also predicted that sleep deprivation will up-regulate ghrelin, and down-regulate circulating oxytocin. Finally, it is predicted that sleep deprivation will increase participants' tendencies to pick larger portions of food, and also increase their tendency to purchase foods that are more caloric in a mock supermarket scenario.

Enrollment: 18 patients

Sex: Male

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Male
• Age 18-35y
• Healthy (self-reported) and not on medication
• Non-smoking
• Normal sleep-wake rhythm (i.e. 7-8 h per night, self-reported)

Exclusion criteria

• Major illness
• Taking any serious medications
• Any sleep conditions (e.g. irregular bedtimes, sleep complaints)
• Any dietary issues with the food items provided
• A history of endocrine or psychiatric disorders

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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18 participants in 2 patient groups

Sleep deprivation

Experimental group

Description:

Total sleep deprivation: participants were required to stay up for the entire night before a 'Blood Sample' was taken and the 'Neuroeconomics task' and 'Portion size task' were performed

Treatment:

Procedure: Blood sample

Behavioral: Neuroeconomics task

Behavioral: Portion Size Task

Sleep

Experimental group

Description:

Sleep: participants had an 8-h sleep opportunity before a 'Blood Sample' was taken and the 'Neuroeconomics task' and 'Portion size task' were performed

Treatment:

Procedure: Blood sample

Behavioral: Neuroeconomics task

Behavioral: Portion Size Task