Sleep Disordered Breathing and Alzheimer's Disease Biomarkers in Normal Aging and Mild Cognitive Impairment

NYU Langone Health

Status

Completed

Conditions

Sleep Disorder

Treatments

Diagnostic Test: VR-CO2 MRI Scans

Diagnostic Test: MRI Based Perfusion Imaging

Diagnostic Test: Structural 3T MRI

Study type

Observational

Funder types

Other

Identifiers

NCT03912571

12-00041

Details and patient eligibility

About

The purpose of this study is to determine the sleep patterns of subjects with or without sleep disturbances (insomnia, sleep apnea) and compare these findings with their previous FDG/PIB PET, structural MRI and brain blood flow scams performed during their participation in the Following studies 'Alzheimer's Disease Core Center (ADCC) Clinical Evaluation' (IRB: 2942), MRI Progression Markers of Cognitive Decline in the Elderly' (IRB:09-0586), or 'Imaging Neuro inflammation in Alzheimer's Disease with [11C] Arachidonic Acid (AA) and PET'(IRB: 10-00442).

Enrollment

28 patients

Sex

All

Ages

55 to 90 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

All subjects will have participated in prior CBH studies and have agreed to an FDG, PIB and MRI scans.

Exclusion criteria

Diagnosis of sleep apnea and under treatment with a continuous positive airway pressure (CPAP) machine.
Active depressive episode during the evaluation with a Geriatric Depression Scale score >7 and/or a Clinical Global Impression scale for depression score >4.
Moderate Cognitive decline (GDS >3).
Severe primary or secondary insomnia except insomnia due to SDB.