Sleep Disturbances as a Non-traditional Risk Factor in CKD-Actigraphy (CRIC)

The University of Chicago

Status: Completed

Conditions: Sleep Loss; Chronic Kidney Disease

Study type: Observational

Funder types: Other

Identifiers

NCT00817674

5R01DK071696 (U.S. NIH Grant/Contract)

#14081A

Details and patient eligibility

About

To test if usual at home night time sleep duration as measured with activity monitors and questionnaires will predict changes in kidney function as measured by kidney filtration rate and of cardiovascular function as measured by C-reactive protein in the blood. The study will explore the role of decreased sleep time or decreased sleep quality as a non-traditional risk factor for the progression of CKD and for the development of cardiovascular disease in CKD.

Enrollment: 353 patients

Sex: All

Ages: 21 to 74 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Mild to Moderate CKD
• Healthy controls age and gender matched to CKD subjects
• Regular bedtimes of at least 6h/night, sedentary lifestyle

Exclusion criteria

• Diabetes
• Current or previous dialysis for more than 1 month
• Uncontrolled hypertension
• Heart failure
• Liver disease
• HIV
• Hemoglobin < 10.5 g/dl
• Treatment with EProcrit, Epogen, or Aranesp
• Bone or organ transplant,
• Use of immunosuppressive drugs within past 6 months
• Current oral contraceptive use
• Current pregnancy
• Chemotherapy for malignancy within past 2 years

Trial design

353 participants in 2 patient groups

1

Description:

CKD subjects

2

Description:

Healthy Controls