Sleep Disturbances as a Risk Factor in Chronic Kidney Disease (CRIC)

The University of Chicago

Status: Completed

Conditions: Chronic Kidney Disease

Treatments: Other: CKD- sleep extension; Other: Controls Short sleep

Study type: Interventional

Funder types: Other

Identifiers

NCT00817427

#14075A

5RO1DK71696-4

Details and patient eligibility

About

This study is designed to determine if either short night time sleep or poor night time sleep could be a risk factor for increasing the rate at which kidney function deteriorates in persons with mild to moderate kidney disease.

Enrollment: 40 patients

Sex: All

Ages: 21 to 74 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Mild to Moderate CKD
• Healthy controls age and gender matched to CKD subjects
• Regular bedtimes of at least 6h/night, sedentary lifestyle

Exclusion criteria

• Diabetes
• Current or previous dialysis for more than 1 month
• Uncontrolled hypertension
• Heart failure
• Liver disease
• HIV
• Hemoglobin < 10.5 g/dl
• Treatment with EProcrit, Epogen, or Aranesp
• Bone or organ transplant,
• Use of immunosuppressive drugs within past 6 months
• Current oral contraceptive use
• Current pregnancy
• Chemotherapy for malignancy within past 2 years

Trial design

40 participants in 3 patient groups

Baseline

No Intervention group

Description:

CKD subjects and healthy, matched controls will have measures of cardiovascular function (BP, HR) measure of hormonal fluid balance (renin/aldosterone) measure and measures of glucose metabolism (response to glucose load and over 24 hr profile) with 3 days of habitual sleep time

CKD- Sleep extension

Experimental group

Description:

Measures as in baseline but with bed time increased by 2 hours

Treatment:

Other: CKD- sleep extension

Controls short sleep

Experimental group

Description:

Measures as in baseline but with sleep disruption

Treatment:

Other: Controls Short sleep