Sleep Extension and Blood Pressure

Mayo Clinic

Status

Completed

Conditions

Sleep Extension

Treatments

Behavioral: sleep maintenance

Behavioral: sleep extension

Study type

Interventional

Funder types

Other

Identifiers

NCT02929810

16-000987

Details and patient eligibility

About

Emerging evidence suggests that approximately 30% of the US adult population sleeps less than 7 hours per night, and those who do exhibit 20-52% enhanced risk to develop cardiovascular diseases and particularly hypertension. Since sleep curtailment is largely voluntary, sleep deficiency can be corrected and its detrimental health consequences potentially reversed. The purpose of the present proposal is to investigate the cardiovascular and metabolic effects of sleep extension in prehypertensive and stage 1 hypertensive subjects who report habitual short sleep.

Enrollment

9 patients

Sex

All

Ages

18 to 65 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Age: 18 to 65 (inclusive)
Gender: both males and females
Body mass index (BMI): 18.5-34.9 kg/m2
Habitual sleep duration: <7 hours
Presence of either:
- Prehypertension: office systolic BP (SBP) 120-139 mmHg and/or diastolic BP (DBP) 80- 89 mmHg;
- Stage 1 hypertension: office SBP 140-159 mmHg and/or DBP 90-99 mmHg
Either on no prescription medications (other than oral contraceptive pills, or intrauterine devices) or on stable medical regimen for at least 1 month, if taking prescription medications for chronic conditions
Not pregnant or breast feeding and not intending to become pregnant or breast feed
Not a current smoker or tobacco user
Ability to provide written informed consent

Exclusion criteria

Vulnerable study populations will be excluded
Pregnancy
Smoking
Presence of overt cardiovascular diseases, diabetes, chronic kidney disease, cancer, sleep disorders, psychiatric disorders
If taking prescription medications for chronic conditions, change in therapy (type, frequency and/or dosage) over the previous month
Habitual sleep duration ≥7 hours
Excessive alcohol (≥15 drinks/week in men and ≥8 drinks/week in women) and/or excessive caffeine intake (>400 mg)
Currently on a diet and/or actively trying to lose weight
Currently or previously (during the past 2 months) participation in any other research study at the discretion of study personnel
Blood/plasma donation during the past 2 months
Unwillingness or inability to adjust sleep schedule.