Sleep Spindles and Memory in Rolandic Epilepsy

Mass General Brigham

Status: Enrolling

Conditions: Centrotemporal Epilepsy; Epilepsy; Rolandic Epilepsy, Benign; Rolandic Epilepsy; Centrotemporal; EEG Spikes, Epilepsy of Childhood; Epilepsy; Seizure

Treatments: Other: Auditory stimulation

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT04569708

1R01NS115868-01 (U.S. NIH Grant/Contract)

2020P002668

Details and patient eligibility

About

The investigators are recruiting children with Rolandic epilepsy and children without epilepsy (aged 4 years old and above) for a non-invasive brain imaging study using Magnetic Resonance Imaging (MRI), Magnetoencephalography/Electroencephalography (MEG/EEG), and experimental tasks. The investigators hope to determine the brain circuits and brain rhythms affected in these children and ultimately identify new treatment options for childhood epilepsy patients.

Full description

This is a prospective study of epilepsy biomarkers in a total of 100 subjects of ages 4-18. Participants will spend about 5 hours at the Massachusetts General Hospital (MGH) Athinoula A. Martinos Center for Biomedical Imaging. They will undergo training on a memory task concurrent with EEG/MEG recordings. During the EEG, subjects will wear headphones that will deliver a quiet pink noise stimulus intermittently during a nap. The auditory stimulus will be calibrated in volume to not cause arousals. After napping, subjects will undergo cognitive testing and memory task testing.

Enrollment: 100 estimated patients

Sex: All

Ages: 4 to 18 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Ages 4-18 years
2. Diagnosed with childhood epilepsy with centrotemporal spikes (CECTS) or Rolandic epilepsy by child neurologist
3. Has EEG with sleep activated centrotemporal spikes
4. Has had at least 1 focal motor or generalized seizure

Exclusion criteria

1. Has abnormal brain MRI

2. Has other unrelated neurological disease

3. Unable to have an MRI/MEG

   1. Claustrophobic
   2. History of frequent vomiting
   3. Permanent metal in body, braces
   4. Over MRI weight limit: 350lbs

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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100 participants in 1 patient group

Children and adolescents with epilepsy and controls

Experimental group

Description:

Closed loop auditory stimulation during nap

Treatment:

Other: Auditory stimulation