Sleep Timing and Insulin Resistance in Adolescents With Obesity

University of Colorado Denver (CU Denver)

Status: Completed

Conditions: Obesity

Study type: Observational

Funder types: Other

Identifiers

NCT02585830

15-0739

UL1TR001082 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

This study examines the relationship between sleep timing and insulin resistance in adolescents with obesity. The investigators also aim to develop a physiologically-based mathematical model of adolescent sleep/wake and circadian interactions.

Enrollment: 25 patients

Sex: All

Ages: 15 to 19 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• High school students between the ages of 15-19
• BMI > 90th percentile
• Tanner stage 2 or greater

Exclusion criteria

• Any medications that affect insulin resistance or sleep (e.g., metformin, hormonal contraception, stimulants, atypical antipsychotics)
• Regular use of melatonin or sleep aids
• A prior diagnosis of obstructive sleep apnea, diabetes (HbA1c > 6.5), liver disease other than non-alcoholic fatty liver disease, pregnancy or breastfeeding
• IQ < 70 or severe mental illness that may impact sleep (e.g., schizophrenia, psychotic episodes)
• Not enrolled in a traditional high school academic program (e.g., home school students)
• Night shift employment
• Travel across more than 2 time zones in the month prior to the study

Trial design