Slow Continuous Ultrafiltration Using Central vs Peripheral Line: Feasibility of Implementation, Safety and Efficacy in Acute Heart Failure Syndromes.

Parc de Salut Mar

Status

Unknown

Conditions

Heart Failure

Treatments

Procedure: Peripheral line

Procedure: Central line vein

Study type

Interventional

Funder types

Other

Identifiers

NCT01630317

ULISES

Details and patient eligibility

About

Slow continuous ultrafiltration using central vs peripheral line: feasibility of implementation, safety and efficacy in acute heart failure syndromes.

Enrollment

33 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

≥ 18 years
Patients hospitalized with primary diagnosis of acute heart failure defined as ≥ 2 of the following criteria:
Peripheral or sacral edema
Jugular venous distension or venous central pressure > 10 mmHg
Hepatomegaly or ascites
Pulmonary edema or pleural effusion on x-ray or pulmonary wedge pressure or end-diastolic pressure > 20 mmHg.
High pro-BNP
Randomization during first 24 hours
Serum creatinine levels < 3mg/dL, and K < 6 mmol/L
The patient should be able to communicate with research staff and meet with study procedures.
The patient will signed informed consent.

Exclusion criteria

Diagnosis of severe aortic stenosis or severe obstruction to the LVOT, tamponade, cardiac hypertrophic or restrictive cardiomyopathy.
Impossibility of venous catheterization
Acute coronary syndrome
Creatinine greater than 3.0 or K greater than 6 mmol/L.
Systolic blood pressure less than or equal to 100 mmHg
Hematocrit greater than 45%
Prior administration of IV vasoactive drugs in the emergency room (ER)
Clinical instability requiring pressors during hospitalization
Sepsis
On or requires renal dialysis.