Slow-wave Sleep Deprivation in Depression

University of Wisconsin (UW)

Status

Completed

Conditions

Major Depressive Disorder

Treatments

Device: Slow-wave deprivation

Study type

Interventional

Funder types

Other

NIH

Identifiers

NCT01189591

H-2007-0150 (Other Identifier)

P20MH077967 NIH grant number

2013-0019

P20MH077967 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

Sleep deprivation can acutely reverse depressive symptoms in patients with major depression. Although underlying mechanisms of the antidepressant action in sleep deprivation are unclear, many of these observations can be explained by abnormal slow wave homeostasis. This study will test the prediction that selectively reducing slow waves during sleep (slow wave deprivation; SWD), without disrupting total sleep time, will yield an antidepressant effect.

Full description

see above

Enrollment

25 patients

Sex

All

Ages

18 to 35 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Among the inclusion criteria will be:
- age range 18-35 years
- right handedness
- major depressive disorder according to DSM-IV (Diagnostic and Statical Manual-Revision 4) criteria (as determined by the Structured Clinical Interview for Diagnostic and Statical Manual-Revision 4), with Hamilton Rating Scale for *Depression scores of at least 18 on the first 17 items
- no psychotropic medications for at least 4 weeks
- no joint and muscular di
- normal hearing
- regular bedtimes and sleep duration, no time zone shifts in the last three weeks.

Exclusion criteria

Diabetes requiring insulin treatment
A serious heart disorder or subjects who have had a heart attack within the last 3 months
A diagnosis of cancer in the past 3 years and/or has active neoplastic disease
Clinically significant abnormalities on pre-study physical exam or physician evaluation
Subjects who meet DSM-IV (Diagnostic and Statical Manual-Revision 4) criteria for alcohol/drug abuse problems within the last six months or are currently using illegal drugs.
Female subjects of child-bearing potential who are pregnant or planning to become pregnant.
Women of child-bearing must be practicing a medically acceptable form of birth control.
Women of childbearing potential will be questioned about pregnancy status and form of birth control to be used at each visit.
Women who are unsure of their pregnancy status will be given a urine pregnancy test.
Subjects taking investigational medications
Subjects currently undergoing electroconvulsive therapy (ECT) or therapeutic transcranial magnetic stimulation (TMS).
Subjects who regularly perform night or late evening shift work (e.g. - "second" or "third" shifts) or have had travel with time zone shifts >3h in the last 3 weeks