Small Airways Disease in Asymptomatic and Symptomatic Subjects With Airway Hyperresponsiveness (AHR) (ABHR)

University Medical Center Groningen (UMCG)

Status

Completed

Conditions

Airway Hyperresponsiveness

Asthma

Study type

Observational

Funder types

Other

Identifiers

NCT01549483

ABHR001

Details and patient eligibility

About

The purpose of this study is to study differences in small airways (<2mm) parameters in asthma patients, subjects with asymptomatic airway hyperresponsiveness and healthy controls.

Enrollment

45 estimated patients

Sex

All

Ages

18 to 65 years old

Volunteers

Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion criteria for asymptomatic subjects with airway hyperresponsiveness (AHR) :

Age between 18 and 65 years.
Forced expiratory volume in one second (FEV1) > 80% predicted post bronchodilator.
Provocative concentration causing a 205 fall in FEV1 (PC20) methacholine <8 mg/ml.
No history of asthma or previous use of asthma medication.

Inclusion criteria for asymptomatic subjects without AHR :

Age between 18 and 65 years.
FEV1 > 80% predicted post bronchodilator.
PC20 methacholine >8 mg/ml.
No history of asthma or previous use of asthma medication.

Inclusion criteria for patients with asthma:

Age between 18 and 65 years.
FEV1 > 80% predicted.
PC20 methacholine ≤8 mg/ml.
Doctor's diagnosis of asthma.
No history of Chronic obstructive pulmonary disease (COPD).

Exclusion Criteria:

Use of inhaled or oral steroids, antihistamines, nedocromil, theophylline, leukotrien antagonists or long-acting beta-agonists for at least three weeks before the start of the study.
Any disease that may affect the outcome of the study as judged by the Investigator.
FEV1 <1.2 liter.