Small Bowel Endoscopic Evaluation in Familial Adenomatous Polyposis (FAP)

University of Sao Paulo

Status: Unknown

Conditions: Familial Adenomatous Polyposis

Treatments: Procedure: Duodenoscopy and enteroscopy; Genetic: Molecular analysis.

Study type: Observational

Funder types: Other

Identifiers

NCT02656134

Small bowel profile in FAP

Details and patient eligibility

About

Background and study aim The relative risks of duodenal adenocarcinoma and ampullary carcinoma in Familial Adenomatous Polyposis (FAP) have been estimated 100 to 330 times higher than in general population. However risk factors, including a genotype-phenotype association for duodenal cancer in FAP has not been fully understood. The aim of this study is to determine risk factors associated with the development of advanced duodenal polyposis and ampullary adenomas in colectomized patients with FAP.

Enrollment: 55 estimated patients

Sex: All

Ages: 15 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with Familial Adenomatous Polyposis with colectomy, or scheduled for surgery.

Exclusion criteria

• Pregnancy, lactation