Small Bowel Motor Impairment in Scleroderma: Results of a Prospective 5-year Manometric Follow-up

University Hospital, Rouen

Status: Completed

Conditions: Systemic Sclerosis

Study type: Observational

Funder types: Other

Identifiers

NCT00213460

2000/103/HP

Details and patient eligibility

About

Small bowel involvement is still recognized to be associated with great morbidity and mortality in SSc patients, leading particularly to malabsorption and intestinal pseudo-obstruction. Intestinal disorders directly related to SSc have, in fact, been reported to be one of the most common causes of death.

In a previous prospective study, we have demonstrated the high prevalence of small intestinal involvement in SSc patients, using upper intestinal manometry; in turn, 88% of our SSc patients had upper intestinal motor disturbances. However, to date, no authors have yet analyzed the course of upper intestinal motor dysfunction in SSc.

The aims of this study were therefore to assess the 5-year course of small bowel motor disorders, using manometry in patients with systemic sclerosis (SSc), and to investigate for an association between upper intestinal motor dysfunction outcome and other clinical manifestations of SSc.

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients with systemic sclerosis, who had an upper intestinal tract manometry 5 years before, with:

  • age over 18 years
  • written informed consent

Exclusion criteria

• pregant women
• patients with psychiatric conditions
• unwritten informed consent