Small Intestinal Bacterial Overgrowth Obese (SIBOB)

Lille Catholic University

Status: Completed

Conditions: Blind Loop Syndrome; Gastric Bypass; Chromatography, Gas; Bacterial Overgrowth Syndrome

Treatments: Procedure: gas chromatography; Procedure: Stool analysis for detection of malabsorption

Study type: Interventional

Funder types: Other

Identifiers

NCT02819037

RC-P0046

2015-A01807-42 (Other Identifier)

Details and patient eligibility

About

The objective of this research is to determine the incidence of microbial overgrowth of the small intestine before and after a gastric bypass. For this purpose, the study is based on the analysis of the expired hydrogen H2 with gas chromatography before surgery and at 1, 3, 6, 12, 18 and 24 months.

Enrollment: 51 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Severe obesity (BMI>35kg/m² with at least one comorbidity or BMI>40kg/m² without comorbidity) and after medical care for at least 6 months
• Patient who will follow bariatric surgery by bypass gastric
• Social insurance affiliation
• Signature of the informed consent

Exclusion criteria

• Contraindication criteria for bariatric surgery (cognitive or mental severe disorders, severe and non-stabilized eating disorders, etc.)
• Chronic inflammatory bowel disease (Crohn's disease, hemorrhagic rectocolitis)
• Previous intestinal surgery
• Antibiotic periodicity treatment of less than 3 months
• Other diseases responsible for bacterial overgrowth
• Pregnancy or breastfeeding

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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51 participants in 1 patient group

Gas chromatography and stool analysis

Experimental group

Description:

gas chromatography and stool analysis for detection of malabsorption

Treatment:

Procedure: Stool analysis for detection of malabsorption

Procedure: gas chromatography