Small Vessel Diseases: Ultra-realistic Microstructure Computational Model to Refine Individual Treatment (SUMMIT-WP3)

Regional University Hospital Center (CHRU)

Status: Enrolling

Conditions: Small Vessel Disease

Treatments: Device: MRI

Study type: Interventional

Funder types: Other

Identifiers

NCT06159140

DR220256 (Registry Identifier)

DR220256-SUMMIT

Details and patient eligibility

About

Small vessel disease (SVD) accounts for 25% of strokes and is the second most common cause of dementia after Alzheimer's disease. Unlike other causes of stroke, SVD manifests itself years before the stroke by the accumulation of tissue damage. Although heterogeneous, these lesions appear on Magnetic Resonance Imaging (MRI) as white matter hypersignals (WMH). In this context, the ANR SUMMIT project will characterize these lesions in vivo to develop new markers in the early stages of stroke. It is subdivided into 4 work packages, the third one being promoted by CHRU de Tours.

Enrollment: 20 estimated patients

Sex: All

Ages: 82 to 100 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

Prior Enrollement in Tours body donation program Age ≥ 82 years Able to remain supine in the MR scanner for acquisition (duration 60-minutes) Affiliation to social security Informed and written consent

Exclusion criteria

Contraindications to body donation, especially infectious disease (VIH, HBV...) Contraindications to MRI

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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20 participants in 1 patient group

Healthy subjects

Experimental group

Description:

MRI and neuropsychological evaluation

Treatment:

Device: MRI