Smoking: a Risk Factor for Pulmonary Arterial Hypertension? (DACH)

University of Zurich (UZH)

Status: Completed

Conditions: Pulmonary Hypertension

Study type: Observational

Funder types: Other

Identifiers

NCT01484899

DACH_1

Details and patient eligibility

About

Environmental factors may play a role in the genesis of pulmonary hypertension, especially in endothelial dysfunction. One widespread environmental factor associated with systemic endothelial dysfunction is cigarette smoke. It may well be that cigarette smoking is not only a risk factor for systemic but also for pulmonary vascular diseases and herewith may interact with other risk factors such as a genetic background and associated conditions. The existing studies which deal with this subject are only small single center case control studies providing less data. Therefore a large European multicenter study is necessary.

The investigators hypothesis are:

• a history of tobacco smoke exposure is highly prevalent in patients with PAH compared to the unaffected general population.
• a history of tobacco smoke exposure is more prevalent in patients with PAH compared to CTEPH.

Enrollment: 500 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• pulmonary artery pressure >25mmHg
• pulmonary capillary occlusion pressure ≤15mmHg

Exclusion criteria

• pulmonary artery pressure <25mmHg
• pulmonary capillary occlusion pressure >15mmHg

Trial design

500 participants in 3 patient groups

PAH

Description:

Patients with pulmonary arterial hypertension (PH). PH defined as mean pulmonary artery pressure \>25mmHg with a pulmonary capillary occlusion pressure ≤ 15mmHg

CTEPH

Description:

Patients with chronic thromboembolic pulmonary hypertension. CTEPH defined as mean pulmonary artery pressure \>25mmHg with a pulmonary capillary occlusion pressure ≤ 15mmHg.

Controll group

Description:

Data from 16322 (10336 females) participants of the Swiss health survey (SHS) 2007 will serve as control. The SHS was performed in 2007, a representative sample of 30000 Swiss citizens were asked to participate, 66% answered per telephone to detailed health question.