Smoking Topography and Harm Exposure in Menthol Cigarettes (MQAT)

University of Pennsylvania

Status

Completed

Conditions

Cigarette Smoking Toxicity

Treatments

Other: Menthol to non-menthol

Study type

Interventional

Funder types

Other

NIH

Identifiers

NCT01329263

812369

P50CA143187 (U.S. NIH Grant/Contract)

P30ES013508 (U.S. NIH Grant/Contract)

R01CA120594 (U.S. NIH Grant/Contract)

R01CA130961 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

This study will examine how menthol affects smoking when menthol smokers switch to non-menthol cigarettes. Participants will smoke their preferred brand (control) or Camel Crush cigarettes, which have the ability to be menthol or non-menthol. Participants given Camel Crush cigarettes will smoke them as menthol, then non-menthol cigarettes for 15 days each. Participants will provide breath and urine samples, track cigarette usage and complete smoking topography assessments of smoking behavior.

Full description

This study will examine how menthol affects smoking behaviors and biomarker level when menthol smokers switch to non-menthol cigarettes. Participants will initially smoke their preferred brand (control) cigarettes, followed by smoking Camel Crush cigarettes, which have the ability to be menthol or non-menthol. Participants given Camel Crush cigarettes will smoke them as menthol, then non-menthol cigarettes for 15 days each. Participants will provide breath and urine samples to measure smoke exposures, track cigarette usage to establish changes in daily cigarette consumption and complete smoking topography assessments of smoking behavior, such as puff volume.

Enrollment

87 patients

Sex

All

Ages

21 to 65 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Self-report smoking daily cigarettes
Self-report smoking menthol flavored cigarettes
Not currently trying to quit or planning to quit in the next 2 months.
Interested in trying a novel cigarette product and willing to smoke a non-menthol cigarette
Self-report smoking only filtered commercially made cigarettes

Exclusion criteria

Self-report drinking equal to or greater than a certain number of alcohol-containing drinks per week
Self report using any nicotine replacement products or nicotine-containing products other than cigarettes
Self-report substance use disorders in the last 5 years
Self-report current Axis I psychiatric disorders
Self-report past history of Axis I psychiatric disorders other than depression
Self-report myocardial infarction, angina or abnormal rhythms requiring medication
Self-report use of select medications and illicit drugs within past six months
Females must not be currently pregnant, planning a pregnancy during the study, or currently breastfeeding/lactating
Provide a baseline carbon monoxide (CO) reading < 10 ppm at initial session
Inability to provide informed consent or complete any of the study tasks as determined by the Principal Investigator