Snooze Control: Sleep Duration & Glucose Metabolism

Xuewen Wang

Status: Completed

Conditions: Glucose Metabolism Disorders

Treatments: Behavioral: OGTT after deprived sleep first; Behavioral: OGTT after sufficient sleep first

Study type: Interventional

Funder types: Other

Identifiers

NCT02583750

Pro00032421

Details and patient eligibility

About

This project investigated how glucose metabolism differs due to sleep deprivation for three consecutive nights as compared to sufficient sleep for three nights by examining concentrations of glucose, insulin, and other factors involved in glucose metabolism.

Full description

16 participants were enrolled in the study (8 females, 8 males) aged 18-25 years. In order for the participants to qualify for the study, each had to wear a pedometer for a week before the study began to determine eligibility. Each participant came to the lab for an oral glucose tolerance test on a morning, following three nights when they were sleep deprived, and on another morning when they had three nights' sufficient sleep. The sequence of the oral glucose tolerance tests were randomly assigned. The sleep duration for participants was monitored by the readings of the sleep monitors that each participant wore. The oral glucose tolerance tests were performed after an overnight fast. A 20-gauge polyethylene catheter was placed in the antecubital vein for blood sampling. Blood samples were drawn once (0 min) before and 4 times (30, 60, 90, and 120 min) after a 75g glucose drink was consumed for the determination of plasma glucose, insulin, and concentrations of other factors. Each participant was told to continue their regular routine during the study period, including diet, caffeine usage, and exercise.

Enrollment: 16 patients

Sex: All

Ages: 18 to 25 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• healthy college-aged males and females
• being minimally active

Exclusion criteria

• average more than 15,000 steps a day
• major health issues such as heart disease, diabetes
• taking medication to help with sleep or using a sleeping device
• any type of sleep problem such as sleep apnea

Trial design

Primary purpose: Health Services Research

Allocation: Non-Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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16 participants in 2 patient groups

OGTT after deprived sleep first

Experimental group

Description:

Participants came to the lab to perform the oral glucose tolerance test after three nights of sleep deprivation, then another test after three nights of sufficient sleep

Treatment:

Behavioral: OGTT after deprived sleep first

OGTT after sufficient sleep first

Experimental group

Description:

Participants came to the lab to perform the oral glucose tolerance test after three nights of sufficient sleep, then another test after three nights of deprived sleep

Treatment:

Behavioral: OGTT after sufficient sleep first