Social Adjustment and Quality of Life After Very Preterm Birth

University Hospital Bonn (UKB)

Status: Completed

Conditions: Premature Birth; Low Birth Weight

Study type: Observational

Funder types: Other; Industry

Identifiers

NCT01163188

01ER0801

Details and patient eligibility

About

The major aim is the follow-up of the highest risk group (< 32 weeks gestation/ < 1500 birthweight) and their controls of the Bavarian Longitudinal Study (BLS) at the age of 24-27 years. The focus will be the identification of risk, protective and resiliency factors for cognitive and behavioural development and quality of life.

MRIs of the central nervous system will be conducted to examine aberrant activation patterns during the "attention network task" in stratified subgroups. Data driven MRI methods will be evaluated in relation to clinical, behavioural and developmental parameters.

Full description

The major aim is the follow-up of the highest risk group (< 32 weeks gestation/ < 1500 birthweight) and their controls of the Bavarian Longitudinal Study (BLS) at the age of 24-27 years. All probands have been assessed previously, neonatally and at additional six time points, the last time at the age of 12-13 years. The focus will be the identification of risk, protective and resiliency factors for cognitive and behavioural development and quality of life. On the basis of previously assessed data statistical modelling of child development until age 8.5 years will be conducted across the total range of gestation from 26-42 weeks to identify social factors amenable to intervention which could be associated with a positive development especially in moderate prematurity. In addition, cross-validation of the findings is planned by means of comparisons with three international studies (Millenium Cohort, GB; POPS, NL; EPICure, GB). MRIs of the central nervous system will be conducted to examine aberrant activation patterns during the "attention network task" in stratified subgroups. Data driven MRI methods will be evaluated in relation to clinical, behavioural and developmental parameters. In line with the objectives of funding there will be a further follow-up of the BLS to answer important questions regarding health and development of very small preterms.

Enrollment: 520 patients

Sex: All

Ages: 24 to 28 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• very low birth weight VLBW (< 1500g birthweight)and/ or
• very preterm birth VPT (< 32 weeks of gestation)
• Members of the Bavarian Longitudinal Study

Exclusion criteria

• missing compliance

Trial design

520 participants in 2 patient groups

Proband

Description:

Very low birth weight children (\< 32 weeks of gestation) and/ or Very preterm children (\< 1500 g birthweight) of the Bavarian Longitudinal Study

Controls

Description:

Term born children of the Bavarian Longitudinal Study