Social Cognition Dysfunctions in Parkinson's Disease (cognition 2)

Civil Hospices of Lyon

Status: Completed

Conditions: Parkinson Disease

Treatments: Behavioral: Quality of life self-questionnaire; Behavioral: social cognition tests

Study type: Observational

Funder types: Other

Identifiers

NCT05230095

2022-A00216-37 (Other Identifier)

69HCL21_1154

Details and patient eligibility

About

Parkinson's disease (PD) is usually responsible of cognitive and behavioral non-motor signs with a major impact on the quality of life. Social cognition is a complex system relying on emotion recognition (neurons mirror system (NMS)), the theory of mind (with its two parts: emotional and cognitive), but also on the social and cultural environment and the personal history. The first step in this model is represented by the NMS, which seems to be altered in PD patients for both positive and negative emotions as shown in our preliminary study. The investigator purpose is to investigate the role of the treatment (levodopa and deep brain stimulation) on the functioning of the NMS

Enrollment: 24 patients

Sex: All

Ages: 30 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

For all participants:

• Man or woman
• Participant not objecting to participation in the study
• Age ≥ 30 and ≤ 70 years old

Specific inclusion criteria for patients:

• Patients with Parkinson's disease with motor fluctuations and dyskinesias receiving deep-brain stimulation
• Patients able to understand the issues of the study

Exclusion criteria

For all participants:

• Person deprived of liberty by judicial or administrative decision
• Person subject to a legal protection measure (tutorship, curatorship)
• Person concurrently participating in another research project who may interfere with the results or conclusions of this study

Specific exclusion criteria for healthy volunteers

• Person presenting or having presented a neurological or psychiatric pathology
• Person with a serious medical condition
• Person who has exceeded the annual amount of compensation authorized for participation in research protocols

Trial design

24 participants in 2 patient groups

Parkinson's disease patients

Description:

30 parkinsonian patients scheduled for deep brain stimulation implantation surgery will be recruited

Treatment:

Behavioral: social cognition tests

Behavioral: Quality of life self-questionnaire

Controls

Description:

15 healthy volunteers matched in age and sex will be recruited

Treatment:

Behavioral: social cognition tests