Social Cognition in Ageing and in Frontotemporal Lobar Degeneration (COSIMAGE)

Caen University Hospital

Status: Unknown

Conditions: Aging; Frontotemporal Lobar Degeneration

Treatments: Behavioral: Cognitive assessment; Other: Brain imaging examination MRI

Study type: Interventional

Funder types: Other

Identifiers

NCT01962064

2011-A00681-40

Details and patient eligibility

About

The purpose of this study is to examine the age and the neurodegenerative disease effects on social cognition. Secondary goals are to better understand the relationships between different component of social cognition, executive functioning, and behavior and describing the neuronal substrates associated to the alteration of the social cognition in ageing and dementia.

Enrollment: 80 estimated patients

Sex: All

Ages: 40 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• All the participants

  • Age between 40 and 80 years
  • Minimum of 7 years of education
  • French native speaker

• Healthy subjects

  • Non pathological Dementia rating scale score

• Patients

  • Clinical diagnosis of frontotemporal lobar degeneration

Exclusion criteria

• Chronic neurological disease
• Encephalitis
• Endocrinal disease
• Hepatic disease
• Case history of head injury with loss of consciousness of more than one hour
• Case history of stroke
• Case history of cancer during the five last years except squamous cell carcinomas
• Alcoholism or drug addiction
• Major psychiatric disorders according the Diagnostic and Statistical Manual of Mental Disorders

Trial design

Primary purpose: Supportive Care

Allocation: Non-Randomized

Interventional model: Factorial Assignment

Masking: None (Open label)

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80 participants in 4 patient groups

Semantic demantia

Experimental group

Description:

cognitive assessment and Brain imaging examination MRI of patient with the semantic variant of primary progressive aphasia

Treatment:

Behavioral: Cognitive assessment

Other: Brain imaging examination MRI

Frontotemporal dementia

Experimental group

Description:

cognitive assessment and Brain imaging examination MRI of patients with the behavioral variant of frontotemporal lobar degeneration

Treatment:

Behavioral: Cognitive assessment

Other: Brain imaging examination MRI

Elderly

Experimental group

Description:

cognitive assessment and Brain imaging examination MRI of healthy elderly subjects

Treatment:

Behavioral: Cognitive assessment

Other: Brain imaging examination MRI

Young

Experimental group

Description:

cognitive assessment and Brain imaging examination MRI of young subjects

Treatment:

Behavioral: Cognitive assessment

Other: Brain imaging examination MRI