Social Cognition Training in Individuals With Huntington's Disease

Rush

Status

Enrolling

Conditions

Huntington's Disease (HD)

Treatments

Behavioral: Social Cognition Training

Study type

Interventional

Funder types

Other

Identifiers

NCT06828471

24112605

Details and patient eligibility

About

Individuals with Huntington's Disease have impaired social cognition, which is the domain of cognition that allows individuals to understand others' perspectives so that they can navigate interpersonal actions successfully (e.g., understanding someone may be sad based of their facial emotion or tone of voice and then responding in a sympathetic manner). Impaired social cognition is associated with impaired social functioning, poor psychological wellbeing and increased caregiver burden, which is known to be significant among those who care for individuals with Huntington's Disease. Computerized social cognition training has been shown to improve social cognition in individuals with schizophrenia, who, like individuals with Huntington's disease, have cognitive impairments. The investigators propose a pilot study of computerized social cognition training in individuals with Huntington's disease. This will be a feasibility study that aims to show that social cognition training in HD can be studied in preparation for a larger randomized controlled trial. The investigators hypothesize that social cognition training can improve social cognition, social functioning, and quality of life in individuals with Huntington's Disease and decrease caregiver burden among those who care for individuals with Huntington's Disease.

Enrollment

20 estimated patients

Sex

All

Ages

18 to 65 years old

Volunteers

No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria for Individual with Huntington's Disease

Diagnosed with Huntington's Disease based on genetic testing
Must be between 18 and 65 years of age
Native English speaker who is literate in English
Stable psychotropic medication regimen for 4 weeks
Must have a score of "somewhat easily" on all items in the CPQ-12
MOCA >18
Completed 12 years of schooling
Access to laptop or mobile device
Willingness to come in person 6-12 weeks after first visit

Inclusion Criteria for Caregiver of Individual with Huntington's Disease

Lives with patient
Must be between 18 and 65 years of age
Native English speaker who is literate in English
MOCA >26
Willingness to come in person within 6-12 weeks after first visit

Exclusion Criteria for Individual with Huntington's Disease

Any known neurological condition (other than Huntington's Disease).
History of learning and/or intellectual disabilities
Currently actively involved in any other interventional trial (i.e. have begun the intervention) or within 4 weeks of completing the final assessments of an interventional trial.
Currently regularly completing a computerized cognitive training intervention.
Active suicidal ideation with some intent

Exclusion Criteria for Caregiver of Individual with Huntington's Disease