Social Dysfunction and Brain Dysfunction in Patients With Schizophrenia

Asan Medical Center

Status: Unknown

Conditions: Schizophrenia; Social Cognition

Study type: Observational

Funder types: Other

Identifiers

NCT01903915

07052012

Details and patient eligibility

About

There were a few studies about the relationship of structural or functional abnormalities of brain and social cognitive dysfunctions in patients with schizophrenia. In addition, default network, which increases activity during mental explorations referenced to oneself including remembering, considering hypothetical social interactions, and thinking about one's own future, may be associated with social cognitive dysfunctions in patients with schizophrenia. Therefore, we will investigate the dysfunction of default network in patients with schizophrenia compared with healthy controls and the effect of default network dysfunctions on the social cognition in patients with schizophrenia.

Enrollment: 100 estimated patients

Sex: All

Ages: 20 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Patients group inclusion criteria:

• Right-handed
• Intelligent Quotient(IQ) above 80
• can read and understand the informed consent
• schizophrenia patients who was diagnosed from Structured Clinical Interview for Diagnostical and Statistical Manual of Mental Disorder 4th edition(DSM-IV, nonpatient version(SCID-NP) scales
• patient who has had reality distortion symptoms (like delusion or hallucination) in 5 years

Control group inclusion criteria :

• Right-handed
• IQ above 80
• do not have any diagnosis from SCID-NP scales
• do not have any family members who have psychiatric disorder

Exclusion criteria:

• have Illness which can affect brain structures and functions
• can't be taken magnetic resonance imaging(MRI)

Trial design

100 participants in 2 patient groups

Patients

Description:

Schizophrenia group

Control

Description:

Healthy control group