Social Effects of Alcohol (SEA)

The University of Chicago

Status and phase: Completed; Early Phase 1

Conditions: Alcohol Drinking

Treatments: Drug: Alcohol; Drug: Placebo

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT05826951

IRB22-1696

5R01DA002812-35 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

In this study the investigator will assess the effect of a moderate dose of alcohol on emotional responses and feelings of connection during a dyadic semi-structured social interaction

Full description

The study will use a within-subject crossover design with four sessions, in which participants receive alcohol or placebo across sessions. During the four sessions, the participants will engage in a conversation with a stranger, and emotional responses and feelings of connection will be assessed.

Enrollment: 37 patients

Sex: All

Ages: 21 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• non-problem alcohol consumption of 2-20 drinks per week
• high school diploma or equivalent
• BMI between 19 and 26
• verbal fluency in English

Exclusion criteria

• High blood pressure
• Any medical condition requiring regular medication
• Individuals with a current (within the last year) DSM-IV Axis 1 diagnosis
• Women who are pregnant or trying to become pregnant.

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Triple Blind

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37 participants in 4 patient groups, including a placebo group

Alcohol-alcohol

Experimental group

Description:

Both conversation partners receive alcohol

Treatment:

Drug: Alcohol

placebo-placebo

Placebo Comparator group

Description:

Both conversation partners receive placebo

Treatment:

Drug: Placebo

alcohol-placebo

Experimental group

Description:

participant receives alcohol and conversation partner receives placebo

Treatment:

Drug: Alcohol

placebo-alcohol

Experimental group

Description:

participant receives placebo and conversation partner receives alcohol

Treatment:

Drug: Placebo