Sociodemographic Factors and Criminal Behaviour Preceding Neurodegenerative Disease - Retrospective Register Study (DEGERWD)

Kuopio University Hospital

Status: Active, not recruiting

Conditions: Multiple System Atrophy; Alzheimer Disease; Frontotemporal Dementia; Corticobasal Degeneration; Neurodegenerative Diseases; Huntington Disease; Parkinson Disease; Vascular Dementia; Amyotrophic Lateral Sclerosis; Progressive Supranuclear Palsy; Lewy Body Disease

Study type: Observational

Funder types: Other

Identifiers

NCT06209515

DEGERWD

Details and patient eligibility

About

In this retrospective register study, clinically classified individuals with neurodegenerative disease from the years 2010-2021 will be verified from the clinical records from KUH and Oulu University Hospital (OUH). Based on the Finnish social security number, these individuals will be linked to the the national registers of Statistics Finland and Finnish Social and Health Data Permit Authority Findata including incomes, sociodemographic factors, education, occupation, criminal records as well as to the national registers including the bought pharmaceuticals, comorbidities and causes of death. For each study case, 10 randomly selected control cases, matched with age, sex and geographical area, will be used.

The aim of the study is to examine:

• 1. The prevalence of criminal and other disruptive behaviour in groups of different neurodegenerative diseases prior to and after the diagnosis
• 2. Changes in employment, residency,income, and marital status prior to and after the neurodegenerative disease diagnosis
• 3. Hospital diagnoses and reimbursable drugs prior to and after the diagnosis
• 4. Causes of death in patients with neurodegenerative disease to study excess mortality of the patients

Enrollment: 61,292 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• The diagnosis of neurodegenerative disease (ICD-10) in KUH or OUH between the years 2010-2021
• Age, sex and residency matched controls (Every research patient has 10 controls matched by age, gender, and place of residency)

Exclusion criteria

• Patients will be divided into different diagnostic groups based on the accepted diagnostic criteria in use. If some of the formed groups contain less than 5 subjects, the disease group in question is excluded from the analyses in order to ensure the privacy protection of the subjects

Trial design

61,292 participants in 2 patient groups

Patients with neurodegenerative disease

Description:

Patient diagnosed with neurodegenerative disease (ICD-10 diagnosis code) between 2010-2021

Matched controls

Description:

Age, gender, and place of residency matched for those of a patient that was alive at the end of the year of the diagnosis