Sodium Channel Mutations in Patient With the Anterior Cutaneous Nerve Entrapment Syndrome (ACNES) (Nav-ACNES)

Maxima Medical Center

Status: Enrolling

Conditions: Chronic Pain Syndrome; Anterior Cutaneous Nerve Entrapment Syndrome; Nerve Entrapment Syndrome

Treatments: Other: Sodium channel mutation

Study type: Observational

Funder types: Other

Identifiers

NCT05877274

NL84021.015.23

Details and patient eligibility

About

The goal of this observational study is to learn about sodium channel (Nav) mutations in patients with the Anterior Cutaneous Nerve Entrapment Syndrome (ACNES). This study will give more insight into the pathophysiology of ACNES, which is still largely unknown.

The primary objective is to determine if there are mutations of Nav1.7 and Nav1.8 in patients with ACNES. Therefore, one blood sample will be drawn, in which the mutations will be analyzed.

Enrollment: 50 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

In order to be eligible to participate in this study, a subject must be diagnosed with ACNES and receive treatment at our outpatient clinic. Additionally, subject has to meet one of the following criteria:

• Known to have a first- or second-degree relative with ACNES;
• Have more than one recurrence of ACNES after a pain free period or ACNES at multiple locations in the abdominal wall;
• Persistent pain after posterior neurectomy.

Exclusion criteria

• Inability to understand Dutch language.
• Known neuromuscular or neurodegenerative disease.

Trial design

50 participants in 1 patient group

Patients with ACNES

Description:

Patients with ACNES who fulfill the inclusion criteria.

Treatment:

Other: Sodium channel mutation