Sodium Chloride vs. Glucose Solute as a Volume Replacement Therapy During Decongestion in Acute Heart Failure (SOLVRED-AHF)

Wroclaw Medical University

Status and phase: Completed; Phase 3

Conditions: Acute Heart Failure; Heart Failure; Congestion

Treatments: Drug: Furosemide intravenous infusion; Drug: Continous intravenous infusion of 0.9% Sodium Chloride solution; Drug: Continous intravenous infusion of 5% Glucose solution

Study type: Interventional

Funder types: Other

Identifiers

NCT05962255

KB-68/2022

Details and patient eligibility

About

The aim of the study is to compare the differences in diuretic, natriuretic and clinical response to decongestion in patients receiving different replacement fluid regimens (0.9% sodium chloride vs 5% glucose) in acute heart failure.

Enrollment: 50 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients >18 years old who sign the informed consent
• the primary cause of hospitalization is Acute Heart Failure with a need for intravenous Furosemide
• the start of the study within 24h of hospital admission

Exclusion criteria

• need for inotropic support
• end stage renal disease on dialysis
• serum sodium > 148mmol/l or < 130 mmol/l.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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50 participants in 2 patient groups

0.9 % Sodium Chloride solution

Experimental group

Description:

Patients receiving an intravenous infusion of 0.9% NaCl

Treatment:

Drug: Continous intravenous infusion of 0.9% Sodium Chloride solution

Drug: Furosemide intravenous infusion

5% Glucose solution

Active Comparator group

Description:

Patients receiving an intravenous infusion of 5% glucose

Treatment:

Drug: Continous intravenous infusion of 5% Glucose solution

Drug: Furosemide intravenous infusion