Sodium Management in Acute and Chronic Heart Failure (SMAC-HF)

Ospedale G. F. Ingrassia

Status: Completed

Conditions: Heart Failure

Study type: Observational

Funder types: Other

Identifiers

NCT01156337

G.F. Ingrassia Hospital,Italy

Details and patient eligibility

About

The study was aimed to verify the effects of Hypertonic saline solution (HSS) and a moderate sodium (Na) restriction plus high furosemide dose in the short term (hospitalization time) and a moderate Na restriction in the long term on readmissions and mortality in patients in III NYHA class.

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Decompensated HF due to ischemic or nonischemic cardiomyopathy,
• >18 years of age,
• HF according to Framingham criteria
• NYHA functional class III
• EF <40%,
• Serum creatinine <2,5 mg/dL
• BUN <60 mg/dL,

Exclusion criteria

• NYHA class > III or < III,
• Cerebral vascular disease,
• Dementia,
• Cancer,
• Uncompensated diabetes,
• Severe hepatic disease
• Patients requiring pacemaker
• Previous RCT implantation
• Alcoholic habit

Trial design

0 participants in 2 patient groups

low sodium diet 80 mmol/day

moderate sodium intake 120 mmol/day